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KMID : 0363320100310010066
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Journal of Korean Oriental Internal Medicine
2010 Volume.31 No. 1 p.66 ~ p.78
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Effects of Astragali Radix (AR) on Chronic Renal Injury in Rats
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Lee Kwun-Ho
Han Yang-Hee
Kim Yong-Sung
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Abstract
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Objective : This study was designed to investigate the possibility of AR for chronic renal injury.
Methods : The author first investigated the expression levels of DNA by inducing of chronic renal injury. Then, the author investigated the effects of AR on chronic renal injury induced by combination treatment with Adriamycin and cisplatin in terms of changes in body weights and renal tissues, urine volume, BUN and creatinine levels, creatinine clearance and histopathological changes in renal tissues. Total expression levels of 546 genes were elevated or lowered by induction of chronic renal injury. Genes of which whose expression levels were elevated by induction of chronic renal injury were related to the PPAR signaling pathway and fatty acid mechanism, etc. Genes of which expression levels were lowered by induction of chronic renal injury were related to the neuroactive ligand-receptor signaling pathway.
Results : Oral administration of AR restored renal mass which was reduced by induction of chronic renal injury. AR also restored creatinine clearance and lowered serum BUN level. In histopathological observation, the AR group has a tendency to prevent tissue damages as shown in the chronic renal injury group.
Conclusions : AR can be used to treat patients with chronic renal injury although further study will be needed to elucidate the exact mechanisms in the efficacy of AR on chronic renal injury.
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KEYWORD
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Chronic renal injury, Astragali Radix (AR), Creatinie, Creatinine cleareance
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